We are an interdisciplinary research group that develops and applies new optical methodologies to study (bio)molecular structure and dynamics. A particular focus rests on the use of light scattering to visualise and quantify the energetics and kinetics of biomolecular interactions all the way from small molecules to mesoscopic structures at the single molecule level. Central to these efforts is the universality of light scattering, making it applicable to all forms of matter and its close correlation with mass, which provides direct information on molecular identity. The result is a comparatively low-resolution combination of cryo-EM and native mass spectrometry, but with the distinct advantage of dynamic solution operation, single molecule sensitivity and imaging capability.
Want to find out more about iSCAT and phase-based microscopy? Join the first (online!) meeting hosted by the Max Planck Institute for the Science of Light. Fantastic group of speakers, great format for discussion, free registration (https://indico.mpl.mpg.de/event/7/)!